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Methotrexate is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat severe cases of psoriasis, rheumatoid arthritis, and some types of cancer. Methotrexate is sometimes prescribed off-label to treat eczema. Methotrexate is sold under the brand names Rheumatrex and Trexall.

Methotrexate is an immunosuppressant. Methotrexate is believed to work by modifying the immune system in several ways — reducing the activity of T cells, B cells, interleukins, and enzymes that play a role in autoimmune attacks.

How do I take it?
Methotrexate is generally prescribed to be taken once or twice each week.

Methotrexate may be taken orally or by intramuscular or intravenous injection.

Side effects
The FDA-approved label for methotrexate lists common side effects including nausea, vomiting, loss of appetite, and temporary hair loss.

Rare but serious side effects listed for methotrexate include infections, birth defects, seizures, and damage to liver, lungs, or kidneys.

For more details about this treatment, visit:

Methotrexate —

Immunosuppressants — National Eczema Association

Methotrexate for Eczema Questions

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