Zorvye (Roflumilast) for Eczema

Overview
Zoryve is a prescription topical treatment approved by the U.S. Food and Drug Administration (FDA) that comes in two forms: a cream and a foam. Zoryve cream is indicated for the treatment of plaque psoriasis in adults and children ages 6 and up. Zoryve foam is indicated for the treatment of seborrheic dermatitis in adults and children 9 and up. Zoryve is sometimes prescribed off-label for people diagnosed with atopic dermatitis (the most common form of eczema). Zoryve is also known by its drug name, roflumilast.

Zoryve belongs to a class of medications known as phosphodiesterase 4 (PDE4) inhibitors. It is thought to work by reducing inflammation, which is a key component of conditions like plaque psoriasis. Although not specifically approved for eczema, treatments that reduce inflammation can be relevant in managing dermatological conditions characterized by inflammation.

How do I take it?
According to the drug’s prescribing information, both Zoryve cream and foam should be applied once daily to the affected areas. It is for topical use only and should not be used in the eyes, orally, or intravaginally. As with any medication, Zoryve should be used exactly as prescribed by a health care provider.

Side effects
Common side effects of Zoryve cream include diarrhea, headache, insomnia, application site pain, upper respiratory tract infections, and urinary tract infections.

Common side effects of Zoryve foam include nasopharyngitis (the common cold), nausea, and headache.

Rare but serious side effects of both Zoryve cream and foam may include an increase in side effects if taken along with systemic CYP3A4 inhibitors or dual inhibitors that inhibit both CYP3A4 and CYP1A2 simultaneously. Additionally, Zoryve foam contains flammable propellants, so people using it should avoid fire, flame, and smoking during and after application.

For more information about this treatment, visit:

Label: Zoryve — Roflumilast Aerosol, Foam — DailyMed

Label: Zoryve — Roflumilast Cream — DailyMed